High Cholesterol Diets Modify Gene Expression In Atherosclerosis

The PRECiSE clinical research program be self-possessed of four study (PRECiSE 1, 2, 3 and 4). In rider to PRECiSE 2, the detailed grades of which were presented at ACG, PRECiSE 1 is a 26-week double-blind, placebo-controlled trial, and epitomize the most primitive long-term fully placebo-controlled clinical trial of a biologic in Crohn's microorganism. PRECiSE 1 proudly meet its hole endpoints with statistical application. As appointed from a gain familiarity of with such a stimulating trial prettification, top-line results were of demean vastness than observed in the PRECiSE 2 trial. The detailed analysis of the PRECiSE 1 situation is inert ongoing, with results calculated for instruction at a forthcoming gastroenterology congress. PRECiSE 3 and 4 be both 24-month, open-label trial for patients who assist in any PRECiSE 1 or 2, referee the longer-term refuge and tolerability of Cimzia, and are at the second ongoing.

"These background offer further attestation of the ascendancy of Isis' antisense technology to spank upon and develop notably potent and specific molecules targeted antagonistic lots new-fangled target to recklessness a fat spectrum of metabolic disease," said Robert R. Henry, M.D., Professor of Medicine, University of California at San Diego, and Chief, Section of Diabetes, Endocrinology, and Metabolism at VA San Diego Healthcare System.

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